Health Information

Cancer Treatment Studies

The York Cancer Center strives to bring the most current cancer therapies available to our community, with respect to treatment, symptom management, and prevention. We continue to collaborate in a large number of National Cancer Institute and industry-sanctioned cooperative group trials. These collaborations have allowed us the opportunity to help bring some cancer treatments to our community that would normally be available only at larger centers or universities.

Our research team continually works to provide the community with a variety of treatment trials. The research team is a dedicated group of professionals who work in conjunction with physicians, nurses and patients to facilitate enrollment in clinical trials, provide protocol therapy and detail collection of research data, which is then submitted to the statistical centers.

The following is a list of the cancer treatment clinical trials that are currently available to our patients in the community.

To learn more about treatment studies, talk to your physician or call us at (717) 741-8100 or (877) 441-7957.

RTOG 0925

Brain

Natural History of Postoperative Cognitive Function, Quality of Life, and Seizure Control in Patients with Supratentorial Low-Risk Grade II Glioma

Record Created: 2013-02-14 12:28:55
RTOG 1122

Brain

Phase II Double-Blinded Placebo-Controlled Study Of Bevacizumab with or without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma

Record Created: 2014-02-12 15:12:38
Alliance A011104

Breast

Effect of Preoperative Breast MRI on Surgical Outcomes, Costs and Quality of Life of Women with Breast Cancer

Record Created: 2013-10-09 15:42:02
Are Memory Changes Precipitated by Endocrine Therapy Treatment in Breast Cancer Patients Previously Treated with Chemotherapy

Breast

Are Memory Changes Precipitated by Endocrine Therapy Treatment in Breast Cancer Patients Previously Treated with Chemotherapy

Record Created: 2011-07-11 11:39:08
ECOG E2108

Breast

A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients with Metastatic Breast Cancer

Record Created: 2011-03-22 10:41:36
NSABP B-43

Breast

A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Record Created: 2009-01-08 12:29:54
NSABP B-50-I

Breast

NSABP B-50-I: A Randomized, Multicenter, Open Label Phase III Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy for Patients with HER2-Positive Primary Breast Cancer Who Have Residual Tumor Present Pathologically in the Breast or Axillary Lymph Nodes Following Preoperative Therapy

Record Created: 2013-04-01 15:19:52
NSABP B-51

Breast

A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

Record Created: 2013-04-17 12:58:05
PBI 3.0 - Open @ York Only - pending JHU approval to initiate

Breast

Multi-Institutional Randomized Trial of Partial Breast Irradiation and Sequential vs. Concurrent Chemotherapy in Women with ER Negative Early Stage Breast Cancer (PBI 3.0)

Record Created: 2014-02-12 15:11:23
Suspended to Enrollment - Management of Radiation Dermatitis with Topical Metronidazole in Breast Cancer

Breast

Management of Radiation Dermatitis with Topical Metronidazole in Breast Cancer

Record Created: 2013-02-21 14:35:55
SWOG S1007 - QOL & Economic Substudy closed 12/01/2012

Breast

A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less

Record Created: 2011-06-06 09:38:52
SWOG S1207

Breast

Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of EVEROLIMUS in Patients with High-Risk Hormone Receptor-Positive AND HER2/neu Negative Breast Cancer. “e3 Breast Cancer Study- evaluating everolimus with endocrine therapy.”

Record Created: 2013-10-08 10:03:41
York Cancer Center Patient Registry

Breast

York Cancer Center Patient Registry: A Study to Compile Information on the Efficacy of High Dose Rate (HDR) Brachytherapy in Providing Radiation Therapy to Breast Cancer Patients

Record Created: 2006-04-03 17:04:28
SWOG S1201

Esophageal

A Randomized Phase II Pilot Study Prospectively Evaluating Treatment for Patients Based on ERCC1 (Excision Repair Cross-Complementing 1) for Advanced/Metastatic Esophageal, Gastric, or Gastroesophageal Junction (GEJ) Cancer

Record Created: 2012-10-22 08:30:47
RTOG 0848

GI

A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma

Record Created: 2010-06-02 13:25:20
SWOG S1201

GI

A Randomized Phase II Pilot Study Prospectively Evaluating Treatment for Patients Based on ERCC1 (Excision Repair Cross-Complementing 1) for Advanced/Metastatic Esophageal, Gastric, or Gastroesophageal Junction (GEJ) Cancer

Record Created: 2014-06-19 09:48:19
ECOG E1311

Head & Neck

A Randomized, Placebo Controlled Phase II Trial of Afatinib (BIBW2992) as Adjuvant Therapy Following Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma at High Risk of Recurrence

Record Created: 2013-10-09 15:43:54
RTOG 0920

Head & Neck

A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally Advanced Resected Head ad Neck Cancer

Record Created: 2010-02-02 14:58:20
RTOG 1016 - closing to enrollment 07.31.2014

Head & Neck

Phase III Trial of Radiotherapy plus Cetuximab versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer

Record Created: 2013-12-23 13:44:47
Alliance A041202

Leukemia

A Randomized Phase III Study of Bendamustine plus Rituximab versus Ibrutinib plus Rituximab versus Ibrutinib Alone in Untreated Older Patients (>/= 65 Years of Age) with Chronic Lymphocytic Leukemia (CLL)

Record Created: 2013-12-24 08:07:04
CALGB 9665

Leukemia

The CALGB Leukemia Tissue Bank

Record Created: 2014-02-12 15:13:50
ECOG E2906

Leukemia

Phase III Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin & Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age ≥60 Years)

Record Created: 2011-01-31 15:30:48
ECOG E3903 - Companion Study to ECOG E2906

Leukemia

Ancillary Laboratory Protocol for the Collection of Diagnostic Material on Patients Considered for ECOG Treatment Trials for Leukemia or Related Hematologic Disorders

Record Created: 2011-02-09 14:46:59
SWOG S1203

Leukemia

A Randomized Phase III Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy or Idarubicin with High Dose Cytarabine (IA) versus IA with Vorinostat (NSC-701852) (IA + V) in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML)

Record Created: 2013-05-07 13:21:06
CALGB C30610/RTOG 0538

Lung

Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

Record Created: 2008-04-23 14:13:40
ECOG E5508

Lung

Randomized Phase III Study of Maintenance Therapy with Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC

Record Created: 2010-09-13 10:19:39
IsoRay Cesium-131

Lung

Cesium-131 Brachytherapy plus Sub-lobar Resection for Early Stage Lung Cancer

Record Created: 2011-02-09 14:44:18
RTOG 0839

Lung

Randomized Phase II Study of Pre-operative Chemoradiotherapy +/- Panitumumab (IND #110152) Followed by Consolidation Chemotherapy in Potentially Operable Locally Advanced (Stage IIIA, N2+) Non-Small Cell Lung Cancer

Record Created: 2011-02-09 14:42:35
SWOG S1400

Lung

S1400: Phase II/III Biomarker-Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer

Record Created: 2014-07-29 13:04:26
ECOG E1412

Lymphoma

Randomized Phase II open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma

Record Created: 2013-08-19 12:33:19
Spectrum SPI-ZEV-11-310

Lymphoma

A Phase 3, Open-Label, Multicenter, Randomized Study of Sequential Zevalin (ibritumomab tiuxetan) Versus Observation in Patients at least 60 Years of Age with Newly Diagnosed Diffuse Large B-Cell Lymphoma in PET-negative Complete Remission after R-CHOP or R-CHOP-Like Therapy (ZEAL)

Record Created: 2012-10-22 08:37:24
ECOG E1A11

Multiple Myeloma

Randomized Phase III Trial of Bortezomib, LENalidomide and Dexamethasone (VRd) versus Carfilzomib, Lenalidomide and Dexamethasone (CRd) Followed by Limited or Indefinite DURation Lenalidomide MantenANCE in Patients with Newly DIagnosed Sympotmatic Multiple Myeloma (ENDURANCE)

Record Created: 2013-11-26 08:53:17
A031201

Prostate

Phase III Trial of Enzalutamide (NSC #766085) versus Enzalutamide, Abiraterone and Prednisone for Castration Resistant Metastatic Prostate Cancer

Record Created: 2014-01-23 09:08:17
RTOG 0534

Prostate

A Randomized Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA after Radical Prostatectomy

Record Created: 2008-03-27 15:04:59
RTOG 0815

Prostate

A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer

Record Created: 2009-10-09 11:57:57
RTOG 0924

Prostate

Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial

Record Created: 2011-08-04 15:26:29
RTOG 1115

Prostate

Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GNRH Agonist vs Dose Escalated Radiation Therapy and Enhanced ADT with a GNRH Agonist and TAK-700 for Men with High Risk Prostate Cancer

Record Created: 2012-05-22 15:09:43
Alliance A221101

Symptom Management

A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil) to Reduce Cancer-Related Fatigue in Patients with Glioblastoma Multiforme

Record Created: 2013-02-14 12:57:46
Alliance A221301 - Pre-activation only - pending activation

Symptom Management

Olanzapine for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV) in Patients Receiving Highly Emetogenic Chemotherapy (HEC): A Randomized, Double-Blind, Placebo-Controlled Trial

Record Created: 2014-07-09 15:06:02