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Cancer Treatment Studies

The York Cancer Center strives to bring the most current cancer therapies available to our community, with respect to treatment, symptom management, and prevention. We continue to collaborate in a large number of National Cancer Institute and industry-sanctioned cooperative group trials. These collaborations have allowed us the opportunity to help bring some cancer treatments to our community that would normally be available only at larger centers or universities.

Our research team continually works to provide the community with a variety of treatment trials. The research team is a dedicated group of professionals who work in conjunction with physicians, nurses and patients to facilitate enrollment in clinical trials, provide protocol therapy and detail collection of research data, which is then submitted to the statistical centers.

The following is a list of the cancer treatment clinical trials that are currently available to our patients in the community.

To learn more about treatment studies, talk to your physician or call us at (717) 741-8100 or (877) 441-7957.

RTOG 0627 - Suspended to Enrollment August 10, 2010

Brain

Phase II Trial of Dasatinib in Patients with Recurrent Glioblastoma Multiforme

Record Created: 2007-04-23 15:39:20
RTOG 0825

Brain

Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab versus Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma

Record Created: 2009-11-24 13:37:24
ACOSOG Z1071

Breast

A Phase II Study Evaluating the Role of Sentinel Lymph Node Surgery and Axillary Node Dissection Following Preoperative Chemotherapy in Women with Node Positive Breast Cancer (T1-4, N1-2, M0) at Initial Diagnosis

Record Created: 2009-08-17 10:22:18
ECOG E5103

Breast

A Double- Blind Phase III Trial of Doxorubicin and Cyclophosphamide followed by Paclitaxel with Bevacizumab or Placebo in Patients with Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer

Record Created: 2008-07-07 10:18:58
J0805 (JH PBIC)

Breast

A Phase I/II Partial Breast Irradiation Concurrent with Chemotherapy

Record Created: 2008-10-15 11:11:53
NSABP B-43

Breast

A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Record Created: 2009-01-08 12:29:54
NSABP B-44-I - BETH Trial - Projected to close September 11, 2010

Breast

A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients with Her2-Positive Node-Positive or High Risk Node-Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab with Chemotherapy Plus Trastuzumab Plus Bevacizumab

Record Created: 2008-06-25 10:39:12
York Cancer Center Patient Registry

Breast

York Cancer Center Patient Registry: A Study to Compile Information on the Efficacy of High Dose Rate (HDR) Brachytherapy in Providing Radiation Therapy to Breast Cancer Patients

Record Created: 2006-04-03 17:04:28
ACOSOG Z4051

Esophageal

A Phase II Study of Neoadjuvant Therapy with Cisplatin, Docetaxel, Panitumumab Plus Radiation Therapy Followed By Surgery in Patients with Locally Advanced Adenocarcinoma of the Distal Esophagus

Record Created: 2009-04-14 14:15:29
RTOG 0436

Esophageal

A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer Who Are Treated Without Surgery

Record Created: 2008-09-04 13:54:49
CALGB C80405

GI

A PHASE III TRIAL OF IRINOTECAN/5-FU/LEUCOVORIN OR OXALIPLATIN/5-FU/LEUCOVORIN WITH BEVACIZUMAB, OR CETUXIMAB (C225), OR WITH THE COMBINATION OF BEVACIZUMAB AND CETUXIMAB FOR PATIENTS WITH UNTREATED METASTATIC ADENOCARCINOMA OF THE COLON OR RECTUM

Record Created: 2008-02-18 12:12:56
ECOG E5202

GI

A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin versus 5-FU, Leucovorin and Oxaliplatin and Bevacizumab in Patients with Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers

Record Created: 2009-05-11 11:30:44
NSABP P-5

GI

Statin Polyp Prevention Trial in Patients with Resected Colon Cancer

Record Created: 2010-05-11 10:56:09
RTOG 0848

GI

A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma

Record Created: 2010-06-02 13:25:20
RTOG 0920

Head & Neck

A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally Advanced Resected Head ad Neck Cancer

Record Created: 2010-02-02 14:58:20
CALGB 140503

Lung

A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (< or = 2 cm) Peripheral NSCLC

Record Created: 2008-02-01 13:37:57
CALGB C36010/RTOG 0538

Lung

Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

Record Created: 2008-04-23 14:13:40
ECOG E1505

Lung

A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients with Completely Resected Stage IB (>4cm) – IIIA Non-Small Cell Lung Cancer (NSCLC)

Record Created: 2007-08-20 12:23:59
ECOG E1508

Lung

A Randomized Phase II Study of Cisplatin and Etoposide In Combination with Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients with Extensive Stage Small Cell Lung Cancer

Record Created: 2009-10-15 15:44:58
RTOG 0937

Lung

Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer (ED-SCLC)

Record Created: 2010-06-17 09:22:22
ECOG E1697

Melanoma

Phase III Randomized Study of Four Weeks High Dose IFN-α2b in Stage T2b No, T3a-b, T4a-b No, and T1-4, N1a, 2a, 3 (microscopic) Melanoma

Record Created: 2008-06-25 10:40:29
ECOG E1A06

Multiple Myeloma

An Intergroup Phase III Randomized Controlled Trial Comparing Melphalan, Prednisone and Thalidomide Versus Melphalan, Prednisone and Lenalidomide in Newly Diagnosed Myeloma Patients Who Are Not Candidates for High-Dose Therapy

Record Created: 2010-06-02 13:29:22
ECOG E3805

Prostate

CHAARTED: ChemoHormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer

Record Created: 2006-10-30 16:00:27
RTOG 0534

Prostate

A Randomized Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA after Radical Prostatectomy

Record Created: 2008-03-27 15:04:59
RTOG 0815

Prostate

A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer

Record Created: 2009-10-09 11:57:57
ECOG E2805 - Closing September 1, 2010

Renal

A Randomized, Double-Blind Phase III Trial of Adjuvant Sunitinib versus Sorafenib versus Placebo in Patients with Resected Renal Cell Carcinoma

Record Created: 2007-03-01 10:23:13
CALGB 170601

Symptom Management

A Phase III Double Blind Trial of Oral Duloxetine for Treatment of Pain Associated with Chemotherapy-Induced Peripheral Neuropathy (CIPN)

Record Created: 2010-06-17 09:21:07
RTOG 0517

Symptom Management

Randomized Phase III Trial to Evaluate Radiopharmaceuticals and Zoledronic Acid in the Palliation of Osteoblastic Metastases from Lung, Breast, and Prostate Cancer

Record Created: 2007-04-23 15:36:58
RTOG 0841 Temporarily Suspended

Symptom Management

Efficiency of Screening for Depression in Cancer Patients Receiving Radiotherapy

Record Created: 2009-08-18 16:17:24