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Cancer Treatment Studies

The York Cancer Center strives to bring the most current cancer therapies available to our community, with respect to treatment, symptom management, and prevention. We continue to collaborate in a large number of National Cancer Institute and industry-sanctioned cooperative group trials. These collaborations have allowed us the opportunity to help bring some cancer treatments to our community that would normally be available only at larger centers or universities.

Our research team continually works to provide the community with a variety of treatment trials. The research team is a dedicated group of professionals who work in conjunction with physicians, nurses and patients to facilitate enrollment in clinical trials, provide protocol therapy and detail collection of research data, which is then submitted to the statistical centers.

The following is a list of the cancer treatment clinical trials that are currently available to our patients in the community.

To learn more about treatment studies, talk to your physician or call us at (717) 741-8100 or (877) 441-7957.

RTOG 0614

Brain

A Randomized, Phase III, Double-Blind, Placebo-Controlled, Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy

Record Created: 2009-01-08 12:06:20
RTOG 0627

Brain

Phase II Trial of Dasatinib in Patients with Recurrent Glioblastoma Multiforme

Record Created: 2007-04-23 15:39:20
ACOSOG Z1071

Breast

A Phase II Study Evaluating the Role of Sentinel Lymph Node Surgery and Axillary Node Dissection Following Preoperative Chemotherapy in Women with Node Positive Breast Cancer (T1-4, N1-2, M0) at Initial Diagnosis

Record Created: 2009-08-17 10:22:18
ECOG E5103 - Temporarily suspended

Breast

A Double- Blind Phase III Trial of Doxorubicin and Cyclophosphamide followed by Paclitaxel with Bevacizumab or Placebo in Patients with Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer

Record Created: 2008-07-07 10:18:58
J0805 (JH PBIC)

Breast

A Phase I/II Partial Breast Irradiation Concurrent with Chemotherapy

Record Created: 2008-10-15 11:11:53
NSABP B-40

Breast

A Phase III Trial of Neoadjuvant Therapy in Patients with Palpable and Operable Breast Cancer Evaluating the Effect on Pathologic Complete Response (pCR) of Adding Capecitabine or Gemcitabine to Docetaxel when Administered Before AC with or without Bevacizumab and Correlative Science Studies Attempting to Identify Predictors of High Likelihood for pCR with Each of the Regimens

Record Created: 2007-01-29 14:28:39
NSABP B-42

Breast

A Clinical Trial to Determine the Efficacy of 5 Years of Letrozole Compared to Placebo in Patients Completing 5 Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women with Hormone Receptor Positive Breast Cancer

Record Created: 2006-10-10 12:29:48
NSABP B-43

Breast

A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Record Created: 2009-01-08 12:29:54
NSABP B-44-I - BETH Trial

Breast

A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients with Her2-Positive Node-Positive or High Risk Node-Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab with Chemotherapy Plus Trastuzumab Plus Bevacizumab

Record Created: 2008-06-25 10:39:12
SWOG S0307

Breast

Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer

Record Created: 2007-01-29 14:36:43
TAILORx Trial

Breast

Trial Assigning Individualized Options for Treatment

Record Created: 2006-08-28 09:12:38
York Cancer Center Patient Registry

Breast

York Cancer Center Patient Registry: A Study to Compile Information on the Efficacy of High Dose Rate (HDR) Brachytherapy in Providing Radiation Therapy to Breast Cancer Patients

Record Created: 2006-04-03 17:04:28
ACOSOG Z4051

Esophageal

A Phase II Study of Neoadjuvant Therapy with Cisplatin, Docetaxel, Panitumumab Plus Radiation Therapy Followed By Surgery in Patients with Locally Advanced Adenocarcinoma of the Distal Esophagus

Record Created: 2009-04-14 14:15:29
RTOG 0436

Esophageal

A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer Who Are Treated Without Surgery

Record Created: 2008-09-04 13:54:49
CALGB C80405

GI

A PHASE III TRIAL OF IRINOTECAN/5-FU/LEUCOVORIN OR OXALIPLATIN/5-FU/LEUCOVORIN WITH BEVACIZUMAB, OR CETUXIMAB (C225), OR WITH THE COMBINATION OF BEVACIZUMAB AND CETUXIMAB FOR PATIENTS WITH UNTREATED METASTATIC ADENOCARCINOMA OF THE COLON OR RECTUM

Record Created: 2008-02-18 12:12:56
ECOG E5202

GI

A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin versus 5-FU, Leucovorin and Oxaliplatin and Bevacizumab in Patients with Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers

Record Created: 2009-05-11 11:30:44
RTOG 0619

Head & Neck

A Randomized Phase II Trial of Chemoradiotherapy versus chemoradiotherapy and Vandetanib for High-Risk Postoperative Advanced Squamous Cell Carcinoma of the Head and Neck

Record Created: 2009-06-11 16:53:45
CALGB 140503

Lung

A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (< or = 2 cm) Peripheral NSCLC

Record Created: 2008-02-01 13:37:57
CALGB C36010/RTOG 0538

Lung

Phase III Comparison of THoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

Record Created: 2008-04-23 14:13:40
ECOG E1505

Lung

A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients with Completely Resected Stage IB (>4cm) – IIIA Non-Small Cell Lung Cancer (NSCLC)

Record Created: 2007-08-20 12:23:59
ECOG E1508

Lung

A Randomized Phase II Study of Cisplatin and Etoposide In Combination with Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients with Extensive Stage Small Cell Lung Cancer

Record Created: 2009-10-15 15:44:58
RTOG L-0127

Lung

Phase III Chemoprevention Trial of Selenium Supplementation in Persons With Resected Stage I Non-Small Cell Lung Cancer.

Record Created: 2006-04-03 17:06:31
ECOG E1697

Melanoma

Phase III Randomized Study of Four Weeks High Dose IFN-α2b in Stage T2b No, T3a-b, T4a-b No, and T1-4, N1a, 2a, 3 (microscopic) Melanoma

Record Created: 2008-06-25 10:40:29
ECOG E3805

Prostate

CHAARTED: ChemoHormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer

Record Created: 2006-10-30 16:00:27
RTOG 0232

Prostate

A Phase III Study Comparing External Beam Radiation and Transperineal Interstitial Permanent Brachytherapy with Brachytherapy Alone in Selected Patients Intermediate Risk Prostatic Carcinoma.

Record Created: 2006-04-03 17:07:53
RTOG 0415

Prostate

A Phase III Study of Hypofractionated 3D-CRT/IMRT versus Conventionally Fractionated 3-D-CRT/IMRT in Patients with Favorable-Risk Prostate Cancer

Record Created: 2007-12-19 13:37:42
RTOG 0534

Prostate

A Randomized Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA after Radical Prostatectomy

Record Created: 2008-03-27 15:04:59
RTOG 0815

Prostate

A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer

Record Created: 2009-10-09 11:57:57
RTOG 0828

Prostate

Pilot Project to Reduce Missing RTOG Quality of Life Data via Electronic Web-Based Form Collection: A Companion Study for RTOG 0415 (A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT Versus Conventionally Fractionated 3D-CRT/IMRT in Patients With Favorable-Risk Prostate Cancer)

Record Created: 2009-07-20 15:41:46
ECOG E2805

Renal

A Randomized, Double-Blind Phase III Trial of Adjuvant Sunitinib versus Sorafenib versus Placebo in Patients with Resected Renal Cell Carcinoma

Record Created: 2007-03-01 10:23:13
RTOG 0517

Symptom Management

Randomized Phase III Trial to Evaluate Radiopharmaceuticals and Zoledronic Acid in the Palliation of Osteoblastic Metastases from Lung, Breast, and Prostate Cancer

Record Created: 2007-04-23 15:36:58
RTOG 0841 Temporarily Suspended

Symptom Management

Efficiency of Screening for Depression in Cancer Patients Receiving Radiotherapy

Record Created: 2009-08-18 16:17:24